# DSIP + Selank

> Combination — not ranked · Combos · reviewed 2026-11-08
> Source page: https://peptidemeta.com/p/dsip-selank/

## Quick answers

**What is DSIP + Selank?**

A sleep-and-calm blend pairing the delta-sleep inducer DSIP with the anxiolytic Selank to promote deep sleep onset while reducing evening anxiety and racing thoughts. Delta sleep-inducing peptide (DSIP) plus Selank.

**What is in DSIP + Selank?**

DSIP + Selank typically combines DSIP and Selank. Commercial products vary.

**How strong is the evidence for DSIP + Selank?**

It is not ranked. A PubMed search found no published studies of this combination; only reviews mention it. DSIP has small human sleep studies, including a double-blind trial in chronic insomnia; Selank has Russian clinical studies.

**Is DSIP + Selank FDA-approved?**

No. DSIP + Selank is not an approved product; no regulator has reviewed the combination.

**Is DSIP + Selank banned in sport?**

No. DSIP + Selank is not on the World Anti-Doping Agency Prohibited List.

**How does DSIP + Selank work?**

This blend targets complementary sleep and anxiety pathways: DSIP modulates GABAergic/glutamatergic neurotransmission to promote delta-wave deep sleep and normalizes the cortisol/ACTH circadian rhythm, while Selank potentiates GABA-A receptor activity and modulates serotonin to reduce pre-sleep anxiety without sedative hangover effects.

**What is known about the safety of DSIP + Selank?**

Both components have been studied in human settings. DSIP is an endogenous peptide with a favorable safety profile.

## Key facts

- **Evidence tier:** not ranked
- **FDA:** not approved
- **WADA:** not on the Prohibited List
- **Peptide:** yes
- **Routes studied:** Subcutaneous, Intramuscular
- **Components:** DSIP, Selank

## Overview

A sleep-and-calm blend pairing the delta-sleep inducer DSIP with the anxiolytic Selank to promote deep sleep onset while reducing evening anxiety and racing thoughts.

## Mechanism

This blend targets complementary sleep and anxiety pathways: DSIP modulates GABAergic/glutamatergic neurotransmission to promote delta-wave deep sleep and normalizes the cortisol/ACTH circadian rhythm, while Selank potentiates GABA-A receptor activity and modulates serotonin to reduce pre-sleep anxiety without sedative hangover effects.

## Effects reported in research

_Reported outcomes, not promises; see the evidence tier._

- Promoted deep restful sleep
- Reduced pre-sleep anxiety
- Improved sleep continuity and duration
- Morning-after calm without grogginess

## Safety & unknowns

Both components have been studied in human settings. DSIP is an endogenous peptide with a favorable safety profile. Selank is approved in Russia without sedation or dependency risks. No combination-specific safety data. Expected to be well-tolerated. Not FDA-approved.

## Studies

- Graf MV, Kastin AJ. (1984). *Delta-sleep-inducing peptide (DSIP): a review*. Neuroscience and Biobehavioral Reviews. Review. https://pubmed.ncbi.nlm.nih.gov/6145137/
  Review of the DSIP component covering its distribution in brain and plasma and reported effects on sleep, electrophysiology, hormones, and circadian patterns.
- Zozulia AA, Neznamov GG, Siuniakov TS, et al. (2008). *[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]*. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. Clinical trial. https://pubmed.ncbi.nlm.nih.gov/18454096/
  Comparative trial of the Selank component versus medazepam in 62 patients with generalized anxiety disorder or neurasthenia, reporting similar anxiolytic effects.

## Status sources

- [Graf & Kastin 1984 — DSIP review](https://pubmed.ncbi.nlm.nih.gov/6145137/)
- [DSIP in chronic insomnia, double-blind study (1992)](https://pubmed.ncbi.nlm.nih.gov/1299794/)
- [Selank in generalized anxiety disorder and neurasthenia (2008)](https://pubmed.ncbi.nlm.nih.gov/18454096/)

---

Educational reference only — not medical advice. No dosing information is published. Tiers rate the strength of published evidence, not effectiveness or safety.