# DSIP

> Evidence tier A — Controlled human trials · Mind · reviewed 2026-11-08
> Source page: https://peptidemeta.com/p/dsip/

Also known as: Delta sleep-inducing peptide, Emideltide, Deltaran

## Quick answers

**What is DSIP?**

Delta sleep-inducing peptide is a nonapeptide isolated from rabbit cerebral venous blood and characterized in 1977, named for its apparent delta-sleep-promoting effect.

**How strong is the evidence for DSIP?**

Tier A (controlled human trials) on the peptidemeta evidence scale. Small double-blind, placebo-controlled trials in chronic insomnia (e.g. Bes et al. 1992, n=16) found weak or no meaningful benefit; registered as a medicine in Russia but not FDA/EMA-approved.

**Is DSIP FDA-approved?**

No. DSIP is not approved by the FDA for any use. Outside the US: Russia — Deltaran® intranasal (registered 2016) for stress-related states and alcohol withdrawal.

**Is DSIP banned in sport?**

No. DSIP is not on the World Anti-Doping Agency Prohibited List.

**How does DSIP work?**

DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) has no identified gene, precursor protein, or specific receptor, so its mechanism and physiological role remain unresolved. Animal studies report effects on sleep, stress hormones, neurotransmitter levels, and opioid-related behaviors.

**What is known about the safety of DSIP?**

Human safety data are limited to small trials from the 1980s-1990s. Rapidly degraded by blood peptidases.

## Key facts

- **Evidence tier:** A (Controlled human trials)
- **FDA:** not approved
- **Other approvals:** Russia — Deltaran® intranasal (registered 2016) for stress-related states and alcohol withdrawal
- **WADA:** not on the Prohibited List
- **Peptide:** yes
- **Sequence:** WAGGDASGE (9 residues)
- **Formula:** C35H48N10O15
- **Molecular weight:** 848.8 g/mol
- **Discovered:** 1977 — Isolated from rabbit blood during induced sleep and characterized by Schoenenberger and Monnier (PNAS 1977).
- **Routes studied:** Subcutaneous, Intramuscular

## Overview

Delta sleep-inducing peptide is a nonapeptide isolated from rabbit cerebral venous blood and characterized in 1977, named for its apparent delta-sleep-promoting effect. Its natural role remains unclear, and controlled human trials found weak or inconsistent effects on sleep.

## Mechanism

DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) has no identified gene, precursor protein, or specific receptor, so its mechanism and physiological role remain unresolved. Animal studies report effects on sleep, stress hormones, neurotransmitter levels, and opioid-related behaviors.

## Effects reported in research

_Reported outcomes, not promises; see the evidence tier._

- Delta-sleep promotion reported in early animal studies
- Shorter sleep latency in one small controlled insomnia trial
- Reported effects on stress-related hormones (mostly animal data)
- Studied for stress-related states and alcohol withdrawal

## Safety & unknowns

Human safety data are limited to small trials from the 1980s-1990s. Rapidly degraded by blood peptidases. Not FDA-approved. Registered in Russia as Deltaran® intranasal (2016).

## Studies

- Bes F, Hofman W, Schuur J, et al. (1992). *Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study*. Neuropsychobiology. Clinical trial. https://pubmed.ncbi.nlm.nih.gov/1299794/
  In a double-blind, placebo-controlled, matched-pairs study of 16 chronic insomniacs, intravenous DSIP gave slightly higher sleep efficiency and shorter sleep latency, but effects were weak and subjective sleep quality did not change; the authors concluded short-term DSIP is unlikely to be of major benefit.

## Status sources

- [PubChem CID 68816 — Emideltide (DSIP)](https://pubchem.ncbi.nlm.nih.gov/compound/68816)
- [Bes et al., Neuropsychobiology 1992 (double-blind trial)](https://pubmed.ncbi.nlm.nih.gov/1299794/)
- [Schoenenberger & Monnier, PNAS 1977 (characterization)](https://pubmed.ncbi.nlm.nih.gov/265572/)
- [RLS drug register (Russia) — Deltaran](https://www.rlsnet.ru/drugs/deltaran-78384)
- [WADA Prohibited List 2026](https://www.wada-ama.org/en/resources/world-anti-doping-code-and-international-standards/prohibited-list)

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Educational reference only — not medical advice. No dosing information is published. Tiers rate the strength of published evidence, not effectiveness or safety.