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No. 028 · Mind · Nootropic Peptide

Selank

TP-7Thr-Lys-Pro-Arg-Pro-Gly-Pro

A Tier A · Controlled human trials how tiers work →
  • Not FDA approved
  • WADA — not listed
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7 residues C33H57N11O9
O O O O O O H O O O H N N N H N N H N H N N 2 H N 2 H N 2 H N 2 H

2D structure from PubChem CID 11765600 (Selank), matched by molecular formula. Hydrogens on carbon are implied.

Selank sequence fingerprint
  • Nonpolar 4
  • Polar 1
  • Positive charge 2

Each dot is a residue placed around the ring from N- to C-terminus; its distance from the centre reflects its chemistry.

01

Quick answers

What is Selank?
A synthetic analog of the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic applications.
How strong is the evidence for Selank?
Tier A (controlled human trials) on the peptidemeta evidence scale. One small randomized trial (62 patients with anxiety disorders, selank vs medazepam, 2008; indexed in PubMed as an RCT), otherwise small Russian clinical studies; registered in Russia but not FDA/EMA-approved.
Is Selank FDA-approved?
No. Selank is not approved by the FDA for any use. Outside the US: Russia — Selank nasal drops 0.15% (Peptogen), registration ЛСР-003338/09.
Is Selank banned in sport?
No. Selank is not on the World Anti-Doping Agency Prohibited List.
How does Selank work?
Selank is a synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension for stability. It has been reported to modulate GABAergic neurotransmission and serotonin metabolism and to affect enkephalin-degrading activity in blood; it also retains immunomodulatory activity related to tuftsin.
What is known about the safety of Selank?
Registered as an anxiolytic in Russia. Published studies, mostly small and from Russian groups, report no sedation or motor impairment.

Last reviewed · editorial policy · markdown

02

Evidence

  1. D In vitro
  2. C Animal
  3. B Human pilot
  4. A RCT
  5. S Approved

TIER A — At least one published randomized controlled trial in humans.

One small randomized trial (62 patients with anxiety disorders, selank vs medazepam, 2008; indexed in PubMed as an RCT), otherwise small Russian clinical studies; registered in Russia but not FDA/EMA-approved.

Tiers rate the strength of published evidence — not effectiveness, safety, or a recommendation.

03

At a glance

Residues
7 amino acids, N→C
Molecular weight
751.9 Da
Formula
C33H57N11O9
Routes studied
Intranasal, Subcutaneous Routes used in published research
FDA
Not approved
Other approvals
  • Russia — Selank nasal drops 0.15% (Peptogen), registration ЛСР-003338/09
WADA
Not on the Prohibited List
04

Sequence

N → C · 7 residues · hover, tap, or use arrow keys to inspect

Note Tuftsin (TKPR) extended with a C-terminal Pro-Gly-Pro.

05

Overview

A synthetic analog of the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic applications. It modulates GABA and serotonin systems without sedation.

Research status Registered in Russia as an anxiolytic; human data limited to small Russian clinical studies, including a 62-patient randomized comparison with medazepam

06

Mechanism

Selank is a synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension for stability. It has been reported to modulate GABAergic neurotransmission and serotonin metabolism and to affect enkephalin-degrading activity in blood; it also retains immunomodulatory activity related to tuftsin.

07

Effects reported in research

Reported outcomes, not promises. Some come from controlled human trials; others may be from smaller or preclinical studies — check the studies below.

  • Reduced anxiety without sedation
  • Enhanced cognitive function under stress
  • Immune system modulation
  • Stabilized mood and emotional balance
08

Safety & unknowns

Registered as an anxiolytic in Russia. Published studies, mostly small and from Russian groups, report no sedation or motor impairment. Not FDA-approved in the US.

Unknowns. Trial safety data apply to the populations, formulations and conditions studied.

Informational only — not medical advice. peptidemeta publishes no dosing, protocols, or sourcing. Talk to a qualified clinician about any treatment decision.

09

Studies [1]

  1. Clinical trial 2008

    Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia

    Zozulia AA, Neznamov GG, Siuniakov TS, et al. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

    In 62 patients with generalized anxiety disorder or neurasthenia, selank and medazepam had similar anxiolytic effects, with selank also showing antiasthenic and stimulant effects; serum enkephalin-related measures were also assessed.

    [pubmed]

11

Status sources

Sources behind the tier, regulatory status, sequence and dates on this page.

12

Cite this entry

$ cite --format=apa

peptidemeta. (2026). Selank. In peptidemeta: The peptide library, ranked by evidence. Retrieved November 8, 2026, from https://peptidemeta.com/p/selank/

$ cite --format=bibtex 
@misc{peptidemeta-selank,
  title = {Selank},
  author = {{peptidemeta}},
  year = {2026},
  howpublished = {\url{https://peptidemeta.com/p/selank/}},
  note = {Accessed 2026-11-08}
}

Accessed date reflects when you opened this page. Cite primary studies for scientific claims.

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